10 new oncology trials approved in Europe


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10 new oncology trials approved in Europe

Good morning, here is a concise selection of oncology and haematology trials first authorised in Europe in the last week.

Sequence Strategy of Immuneoncology (IO-IO) vs IO-tyrosine kinase inhibitors (TKI) followed by TKI in metastatic renal cell carcinoma (mRCC): A randomized phase 3 study MeetURO and FICOG trial

Sponsor: Fondazione IRCCS Istituto Nazionale Dei Tumori Phase: 3

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BiFAST: A phase II trial evaluating fixed dose and faster ramp-up of epcoritamab with lenalidomide for 3L relapse/refractory large B-cell lymphoma after CAR T-cells therapy in 2nd line

Sponsor: LYSARC Phase: 2

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Hyperthermic Intraperitoneal Chemotherapy and Regional Adrenalectomy in the management of Stage II & III Adrenocortical Carcinoma

Sponsor: Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia Phase: 2

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A phase II, open-label, randomized, multi-center study comparing the efficacy and safety of Sacituzumab govitecan versus investigator’s choice in patients with cancer of unknown primary (CUP) who are relapsed after or refractory to platinum-based chemotherapy

Sponsor: Universitaetsklinikum Heidelberg AöR Phase: 2

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A Phase III Open-Label, Randomised, Multicentre Study of Consolidation with a Single Administration of AZD0120, a Dual-Targeting Autologous Chimeric Antigen Receptor T-cell (CAR T) Therapy Directed Against BCMA and CD19, Compared with Continuous Standard Therapy in Participants with NDMM Who Are Ineligible to Receive ASCT as Initial Therapy (DURGA-5).

Sponsor: AstraZeneca AB Phase: 3

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PRadR 2 - A single center, open-label, Phase I study evaluating 161Tb-PSMA therapy in adult patients with metastatic clear cell renal cell carcinoma

Sponsor: Centre Leon Berard Phase: 1

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Perioperative zanidatamab combined with chemotherapy in HER2-positive locally advanced operable gastroesophageal adenocarcinoma (GEA): a Phase 1b/2a single-arm trial

Sponsor: UZ Leuven Phase: 1, 2

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HOVON 168: Epcoritamab in Addition to R-Mini-CHOP Compared to R-Mini-CHOP in Elderly, Frail or Unfit Patients with Diffuse Large B-cell Lymphoma

Sponsor: Hemato-Oncologie voor Volwassenen Nederland (Hovon) Stichting Phase: 2

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A Phase II, single-arm trial on the addition of the DLL3xCD3 bispecific T-cell engager obrixtamig (BI 764532) to standard-of-care platinum-based first-line treatment of advanced large-cell neuroendocrine carcinoma of the lung

Sponsor: Technische Universitaet Dresden Phase: 2

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A PHASE III, RANDOMIZED, OPEN-LABEL STUDY EVALUATING THE EFFICACY AND SAFETY OF DIVARASIB COMPARED WITH INVESTIGATOR’S CHOICE OF IMMUNOTHERAPY OR OBSERVATION IN PATIENTS WITH RESECTED STAGE II-III KRAS G12C-POSITIVE NON-SMALL CELL LUNG CANCER

Sponsor: F. Hoffmann-La Roche AG Phase: 3

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