8 new oncology trials approved in Europe


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8 new oncology trials approved in Europe

Good morning, here is a concise selection of oncology and haematology trials recently authorised in Europe.

RINGQUEST: Exploring Understudied Genitourinary Tumors with Sacituzumab Tirumotecan; a Single-arm, Basket, Phase II Study.

Sponsor: Alianza Multidisciplinar Para La Investigacion De Los Tumores Genitourinarios Guard Phase: 2

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[18F] MC225 PET analysis of Blood-Brain Barrier Function in Glioblastomas

Sponsor: Universitair Medisch Centrum Groningen Phase:

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PHOENIX-ECP: A Phase 2, Randomized, Controlled, Open-label, Multicenter Study to Evaluate the Efficacy and Safety/Tolerability of Extracorporeal Photopheresis (ECP) Versus Best Available Therapy (BAT) for the Treatment of Immune-related Colitis and/or Hepatitis with Inadequate Response to Corticosteroids in Participants with Unresectable or Metastatic Melanoma Treated with Immune Checkpoint Inhibitors

Sponsor: Therakos Europe Limited Phase: 2

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A phase 2, open-label, Multicenter, Randomized study of Trastuzumab Deruxtecan versus investigator’s choice chemotherapy in recurrent ovarian cancer that progressed on prior PARP inhibitor therapy: TROY (APGOT-OV14)

Sponsor: Fundacion Grupo Espanol De Investigacion En Cancer Ginecologico Phase: 2

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A Phase 1/2, Multicenter, First-in-Human, Dose Escalation and Expansion Study Evaluating CHM-029, as Monotherapy and in Combination with Standard Therapies in Participants with Relapsed or Refractory, or Newly Diagnosed Acute Myeloid Leukemia (AML) with NPM1 Mutations, KMT2A or NUP98 Rearrangements

Sponsor: Charm Therapeutics Limited Phase: 1, 2

Not accepting new sites

Pharmacokinetic study of pembrolizumab and its impact on immunity and the tumor microenvironment, which may explain the efficacy of post-immunotherapy chemotherapy

Sponsor: Centre Antoine Lacassagne Phase: 4

Not accepting new sites

PROOF OF CONCEPT: FEASIBILITY OF PHOTODYNAMIC DIAGNOSIS IN BLADDER CANCER PATIENTS WITH SUB-ONE-HOUR INSTILLATION TIME OF HEXAMINOLEVULINATE (HEXVIX®)

Sponsor: Institut Paoli Calmettes Phase: 2

Not accepting new sites

ROSETTA RCC-208: A Phase 1/2 Open-label, Multi-center, Randomized Study of Pumitamig Alone or in Combination with Ipilimumab or Cabozantinib in Participants with Advanced Renal Cell Carcinoma (RCC)

Sponsor: Bristol-Myers Squibb Services Unlimited Company Phase: 1, 2

Not accepting new sites

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