Oncology Hero

15 new oncology trials approved in Europe

Good morning, here is a concise selection of oncology and haematology trials first authorised in Europe in the last week.

Use of the Checkpoint inhibitor DOstarlimab in the endOmetrial cancer fertility-Sparing trEatment: CHOOSE study

Sponsor: UZ Leuven

Phase: 2

Interested in offering this trial to suitable patients?

Antibody-based PET imaging and treatment response in breast cancer treated with an antibody-drug conjugate according to current standard indications.

Sponsor: Unicancer

Phase: 2

Interested in offering this trial to suitable patients?

A Phase III, Open-Label, Randomised, Multicentre, Global Study of Adjuvant Datopotamab Deruxtecan in Combination With Rilvegostomig in Participants With High-risk Muscle Invasive Urothelial Carcinoma (TROPION-Urothelial04).

Sponsor: AstraZeneca AB

Phase: 3

Interested in offering this trial to suitable patients?

A randomized, open-label, multicenter, Phase 3 study to investigate mocertatug rezetecan compared with standard of care in participants with platinum- resistant ovarian cancer.

Sponsor: Glaxosmithkline Research & Development Limited

Phase: 3

Interested in offering this trial to suitable patients?

A randomized, open-label, multicenter, Phase 3 study to investigate mocertatug rezetecan compared with chemotherapy in participants with endometrial cancer after platinum-based chemotherapy and immunotherapy

Sponsor: Glaxosmithkline Research & Development Limited

Phase: 3

Interested in offering this trial to suitable patients?

A Randomized Phase 2/3 Study of Ivonescimab in Combination with Enfortumab Vedotin vs Pembrolizumab in Combination with Enfortumab Vedotin in Previously Untreated Locally Advanced or Metastatic Urothelial Carcinoma (HARMONi-GU1)

Sponsor: Summit Therapeutics Inc.

Phase: 2, 3

Interested in offering this trial to suitable patients?

A Randomized, Open-label, Phase 3 Study of Rina-S ± Bevacizumab Versus Investigator's Choice of Platinum-Based Chemotherapy ± Bevacizumab as 2L Treatment in Participants With Recurrent Platinum-Sensitive Ovarian Cancer

Sponsor: Genmab A/S

Phase: 3

Interested in offering this trial to suitable patients?

Antibiotic Prophylaxis in Hematopoietic Stem Cell Transplantation: a Randomised Controlled Trial - The ANTURA trial

Sponsor: HUS-yhtymae

Phase: 4

Interested in offering this trial to suitable patients?

A multicentre, randomized, open label study comparing the concomitant administration of trabectedin and low-dose radiotherapy versus trabectedin alone in patients with advanced sarcoma

Sponsor: Instituto De Investigacion Sanitaria Fundacion Jimenez Diaz

Phase: 4

Interested in offering this trial to suitable patients?

BASTION – Phase II Trial of BrECADD in HIV-Positive Patients with Advanced-Stage Classic Hodgkin Lymphoma

Sponsor: University Of Cologne

Phase: 2

Interested in offering this trial to suitable patients?

A Long-Term Follow-Up Study of Subjects Completing the AU-011-301 (CoMpass) Trial of Bel-sar for Early Choroidal Melanoma (Indeterminate Lesions/Small Choroidal Melanomas)

Sponsor: Aura Biosciences Inc.

Phase:

Interested in offering this trial to suitable patients?

A phase III, randomised, double-blind, placebo-controlled, multicentre trial comparing efficacy and safety of trilaciclib versus placebo in participants with limited-stage small cell lung cancer

Sponsor: Pharmacosmos A/S

Phase: 3

Interested in offering this trial to suitable patients?

A Phase 3 Randomized, Open-Label Study of Atebimetinib in Combination with the Modified Gemcitabine and nab-Paclitaxel Regimen Versus the Standard Gemcitabine and nab-Paclitaxel Regimen for the Treatment of Patients with Metastatic Pancreatic Ductal Adenocarcinoma Cancer (MAPKeeper 301)

Sponsor: Immuneering Corp.

Phase: 3

Interested in offering this trial to suitable patients?

Prevention of Venous Thromboembolism in Patients with Cirrhosis and Hepatocellular Carcinoma

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Phase: 3

Interested in offering this trial to suitable patients?

A follow-up extension study of patients who completed the U-LaserPrint-1 clinical trial to evaluate the long-term safety and efficacy of treatment with InvivoLPrint-U.

Sponsor: Phosprint S.A.

Phase: 1

Interested in offering this trial to suitable patients?

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Oncology Hero

15 new oncology trials approved in Europe

15 new oncology trials approved in Europe

Use of the Checkpoint inhibitor DOstarlimab in the endOmetrial cancer fertility-Sparing trEatment: CHOOSE study

Antibody-based PET imaging and treatment response in breast cancer treated with an antibody-drug conjugate according to current standard indications.

A Phase III, Open-Label, Randomised, Multicentre, Global Study of Adjuvant Datopotamab Deruxtecan in Combination With Rilvegostomig in Participants With High-risk Muscle Invasive Urothelial Carcinoma (TROPION-Urothelial04).

A randomized, open-label, multicenter, Phase 3 study to investigate mocertatug rezetecan compared with standard of care in participants with platinum- resistant ovarian cancer.

A randomized, open-label, multicenter, Phase 3 study to investigate mocertatug rezetecan compared with chemotherapy in participants with endometrial cancer after platinum-based chemotherapy and immunotherapy

A Randomized Phase 2/3 Study of Ivonescimab in Combination with Enfortumab Vedotin vs Pembrolizumab in Combination with Enfortumab Vedotin in Previously Untreated Locally Advanced or Metastatic Urothelial Carcinoma (HARMONi-GU1)

A Randomized, Open-label, Phase 3 Study of Rina-S ± Bevacizumab Versus Investigator's Choice of Platinum-Based Chemotherapy ± Bevacizumab as 2L Treatment in Participants With Recurrent Platinum-Sensitive Ovarian Cancer

Antibiotic Prophylaxis in Hematopoietic Stem Cell Transplantation: a Randomised Controlled Trial - The ANTURA trial

A multicentre, randomized, open label study comparing the concomitant administration of trabectedin and low-dose radiotherapy versus trabectedin alone in patients with advanced sarcoma

BASTION – Phase II Trial of BrECADD in HIV-Positive Patients with Advanced-Stage Classic Hodgkin Lymphoma

A Long-Term Follow-Up Study of Subjects Completing the AU-011-301 (CoMpass) Trial of Bel-sar for Early Choroidal Melanoma (Indeterminate Lesions/Small Choroidal Melanomas)

A phase III, randomised, double-blind, placebo-controlled, multicentre trial comparing efficacy and safety of trilaciclib versus placebo in participants with limited-stage small cell lung cancer

A Phase 3 Randomized, Open-Label Study of Atebimetinib in Combination with the Modified Gemcitabine and nab-Paclitaxel Regimen Versus the Standard Gemcitabine and nab-Paclitaxel Regimen for the Treatment of Patients with Metastatic Pancreatic Ductal Adenocarcinoma Cancer (MAPKeeper 301)

Prevention of Venous Thromboembolism in Patients with Cirrhosis and Hepatocellular Carcinoma

A follow-up extension study of patients who completed the U-LaserPrint-1 clinical trial to evaluate the long-term safety and efficacy of treatment with InvivoLPrint-U.

9 new oncology trials approved in Europe

12 new oncology trials approved in Europe

11 new oncology trials approved in Europe